New research suggests the ketogenic or keto diet plan might prove beneficial in helping cure some types of cancer by increasing the effectiveness of chemotherapy and other drugs.
The key to success is keeping blood glucose under control. The keto diet does just that by restricting carbs to a minimum.
It consists of high fat foods and also consists of foods with an adequate amount of protein and a very low amount of carbs. Glucose is stemmed from sugar that is present in carbs.
The method the keto diet plan works and the factor why it's being thought about as part of a treatment to cure some forms of cancer, is that it denies the body of glucose. This glucose deprivation induces a state called "ketosis.".
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In ketosis, the body is forced to use stored fat in the kidneys instead of sugar to produce an alternative source of energy.
A brand-new study explores the keto diet plan as a possible avenue for treatment of particular forms of cancer. A team of researchers from the University of Texas at Dallas restricted the levels of circulating glucose in mice by feeding them a ketogenic diet and administering a diabetes drug that stops the reabsorption of blood sugar level in the kidneys.
The scientists released their paper in the journal Cell Reports. An assistant teacher of biological sciences at the University of Texas at Dallas, Jung-Whan Kim, is the matching author of the new research study while Meng-Hsiung Hsieh is the first author.
Formerly, a cancer type called squamous cell cancer (SCC) relies heavily on glucose to sustain its "antioxidative capability and survival" compared to other types of cancers, according to Kim and his group.
The group reasoned limiting glucose must make SCC more vulnerable to treatment. To test this theory, they fed mice with xenograft tumors with either a ketogenic diet consisting of 0.1% carbs or a typical diet.
" Xenograft tumor growth of lung SCC [...] and esophageal SCC [...] was significantly hindered upon ketogenic diet plan as compared to typical chow fed groups," stated the research study.
Kim kept in mind that both the ketogenic diet plan and the pharmacological limitation of blood glucose by themselves prevented the more development of SCC growths in mice with lung cancer. On the other hand, the glucose limitation did not impact non-SCC growths.
" While these interventions did not diminish the tumors, they did keep them from progressing, which suggests this type of cancer may be vulnerable to glucose constraint.".
Kim said their results recommend this method is "cancer cell type particular. We can not generalize to all kinds of cancer.".
Kim said the essential finding of their brand-new study in mice is that a ketogenic diet alone does have some tumor growth inhibitory effect in SCC. But when the team combined this with a diabetes drug and chemotherapy, the treatment was much more efficient.
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